4 results for "Voltage-gated Sodium Channel Inhibitors" in Products
Voltage-gated Sodium Channel Inhibitors
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.
Structurally, NaV channels are composed of one pore-forming α-subunit, which may be associated with either one or more β-subunits. α-subunits are composed of four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.
Anticonvulsant; inhibits Na+ channel activity
| Chemical Name: | 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide |
| Purity: | ≥98% |
Active metabolite of oxcarbazepine (Cat. No. 3864)
| Alternate Names: | GP 47779 |
| Chemical Name: | 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| Purity: | ≥98% |
Inhibitor of neuronal NaV channels; anticonvulsant
| Alternate Names: | CBZ |
| Chemical Name: | 5H-Dibenz[b,f]azepine-5-carboxamide |
| Purity: | ≥98% |
Potent and selective state-independent inhibitor of NaV1.8 sodium channels
| Chemical Name: | (R)-2-(4-Fluoro-2-methylphenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide |
| Purity: | ≥98% |
