CBL Antibody

Name: CBL Antibody
Brand: Novus Biologicals
SKU: NB100-869
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-869

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Citations (1)

Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Mouse

Predicted:

Bovine (100%), Canine (100%), Human (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all CBL Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-REFVSISSPAHVAT corresponding to C-Terminus according to NP_005179.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Description

Novus Biologicals Goat CBL Antibody (NB100-869) is a polyclonal antibody validated for use in WB and ELISA. Anti-CBL Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for CBL Antibody

Western Blot: CBL Antibody [NB100-869]

Western Blot: CBL Antibody [NB100-869] - staining (2 ug/ml) of 3T3 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Applications for CBL Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

1 - 3 ug/ml

Application Notes

WB: Approx. 120 kDa band observed in 3T3 lysate.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CBL

The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBLs interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.

Long Name

Casitas B-lineage Lymphoma, E3 Ubiquitin Protein Ligase CBL

Alternate Names

CBL2, RNF55

Entrez Gene IDs

867 (Human); 12402 (Mouse)

Gene Symbol

CBL

UniProt

NP_005179. (Human)

Additional CBL Products

Product Documents for CBL Antibody

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Certificate of Analysis

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Product Specific Notices for CBL Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

E3 Ubiquitin Ligases

Citations for CBL Antibody

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