High affinity and subtype selective α
2 and α
2 partial agonist (Ki
values are 12 and 26nM for rat α
2 and α
2 receptors respectively). Has low affinity for α
4 and α
7 receptors (Ki
values are 4.8 and 13 μ
M for human α
4 and rat α
7 receptors respectively). Stimulates dopamine release from striatal slices in vitro
. Attenuates nicotine-induced self-administration and conditional place preference in rats.
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All Tocris products are intended for laboratory research use only.
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