CG 428

Tocris Bioscience | Catalog # 7425

Potent tropomyosin receptor kinase (TRK) Degrader
Tocris Bioscience

Key Product Details

Description

Potent tropomyosin receptor kinase (TRK) Degrader
View all Active Degraders »

Product Description

CG 428 is a potent tropomyosin receptor kinase (TRK) Degrader (uSMITE™) (DC50 = 0.36 nM). CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). CG 428 shows selectivity for TRKA over TRKC and TRKB (Kd values = 1nM, 4.2 nM and 28 nM, respectively). Inhibits growth of KM12 colon cancer cells (IC50 =2.9 nM) and is bioavailable.

Negative control CG 428-Neg (Cat. No. 7426), and TrkB antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF1494 and AF397.

Licensing Information

Sold under license from Cullgen

Product Specifications for CG 428

Molecular Weight

814.88

Formula

C43H43FN10O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1H-isoindole-1,3(2H)-dione

CAS Number

2412055-93-5

PubChem ID

146410727

InChI Key

FWANKJAOTQAHHR-KWRHIPAJSA-N

SMILES

FC1=CC=CC([C@H]2CCCN2C3=NN4C(C=C3)=NC=C4C5=NC(N6CCN(C(CCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O)=O)CC6)=CC=C5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.49 100

Preparing Stock Solutions for CG 428

The following data is based on the product molecular weight 814.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.23 mL 6.14 mL 12.27 mL
5 mM 0.25 mL 1.23 mL 2.45 mL
10 mM 0.12 mL 0.61 mL 1.23 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CG 428

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CG 428

For research use only

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