Catalog Number: 2639
Chemical Name: α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Biological Activity
Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
Technical Data
  • M.Wt:
    555.84
  • Formula:
    C23H18Cl3FN4O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    905973-89-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy.
    Crescenzi et al.
    Clin.Cancer Res., 2008;14:1877
  2. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
    Alao and Sunnerhagen
    Radiat.Oncol., 2009;10:4
  3. Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells.
    Bhattacharya et al.
    Cell Signal., 2009;21:509
  4. Retraction: small molecule-based reversible reprogramming of cellular lifespan.
    Won et al.
    Nat.Chem.Biol., 2008;4:431
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGK 733 include:

1 Citations: Showing 1 - 1

  1. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle 2013;13:408

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