CGK 733

  ( 2 citations )    
Product Datasheet
Catalog Number:2639
Chemical Name:α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Product Details
Citations (2)
Reviews
Biological Activity
Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
Technical Data
  • M.Wt:
    555.84
  • Formula:
    C23H18Cl3FN4O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    905973-89-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGK 733 include:

2 Citations: Showing 1 - 2
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  1. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  2. Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.
    Authors: Labay Et al.
    Int J High Throughput Screen  2011;2:1

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