Chemical Name: α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Biological ActivityOriginally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells.
Bhattacharya et al.
Cell Signal., 2009;21:509
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
Alao and Sunnerhagen
Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy.
Crescenzi et al.
Clin.Cancer Res., 2008;14:1877
Retraction: small molecule-based reversible reprogramming of cellular lifespan.
Won et al.
Citations for CGK 733
The citations listed below are publications that use Tocris products. Selected citations for CGK 733 include:
3 Citations: Showing 1 - 3
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
Authors: Fard Et al.
Cell Cycle 2013;13:408
Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication.
Authors: Luo Et al.
J Virol 2011;85:8046
Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.
Authors: Labay Et al.
Int J High Throughput Screen 2011;2:1
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