Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1
levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy.
Crescenzi et al.
Clin.Cancer Res., 2008;14:1877
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
Alao and Sunnerhagen
Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells.
Bhattacharya et al.
Cell Signal., 2009;21:509
Retraction: small molecule-based reversible reprogramming of cellular lifespan.
Won et al.
The citations listed below are publications that use Tocris products. Selected citations for CGK 733 include:
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