Ch 55

Catalog # Availability Size / Price Qty
2020/10
2020/50
Ch 55 | CAS No. 110368-33-7 | Retinoic Acid Receptor Agonists
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Description: Potent RAR agonist

Chemical Name: 4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM).

Technical Data

M.Wt:
364.47
Formula:
C24H28O3
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
110368-33-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein.
    Jetten et al.
    Cancer Res., 1987;47:3523
  2. Functional studies of newly sythesized benzoic acid derivatives: identification of highly potent retinoid-like activity.
    Sato et al.
    J.Cell.Physiol., 1988;135:179
  3. Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's).
    Hashimoto et al.
    Biochem.Biophys.Res.Comm., 1990;166:1300

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Citation for Ch 55

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