Catalog Number: 4504
Chemical Name: (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4
Biological Activity
Histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
Technical Data
  • M.Wt:
    696.84
  • Formula:
    C30H28N6O6S4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    28097-03-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.
    Isham et al.
    Blood, 2007;109:2579
  2. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.
    Greiner et al.
    Nat.Chem.Biol., 2005;1:143
  3. Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.
    Cherblanc et al.
    Nat.Chem.Biol., 2013;9:136
  4. Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".
    Greiner et al.
    Nat.Chem.Biol., 2013;9:137

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