Chicken Caronte, the ortholog of mammalian Cerberus, is a member of the Cerberus/DAN family of secreted glycoproteins. There are at least 5 Dan Domain (DAND) family members including DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), Cerberus (DAND4), and Coco (DAND5). Caronte is expressed in the left paraxial mesoderm and is the molecule responsible for transducing left-sided positional information from the node to the periphery of the lateral plate mesoderm (LPM) during chicken embryonic development. Caronte functions as a BMP antagonist, inducing Nodal and downstream genes in the LPM by interfering with the repressive activity of bilaterally-produced BMPs. In addition, antagonism of BMPs by Caronte induces the expression of the Lefty gene in the midline. Caronte binds both BMP-4 and BMP-7 in immunoprecipitation experiments. Recombinant chicken Caronte preparations from R&D Systems have been shown to bind BMP-4 in a functional ELISA and induce heart reversals in Xenopus embryos.
Chicken Caronte Alexa Fluor™ Plus 555‑conjugated Antibody
R&D Systems | Catalog # AF1051AFP555
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Chicken Caronte Alexa Fluor™ Plus 555‑conjugated Antibody
Blockade of Receptor-ligand Interaction
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: Caronte
References
- Pearce, J. et al. (1999) Dev. Biol. 209:98.
- Yokouchi, Y. et al. (1999) Cell. 98:573.
- King, T. and N. Brown (1999) Nature 401:222.
- Ahu, L. et al. (1999) Curr. Biol. 9:931.
- Rodriguez-Esteban, C. et al. (1999) Nature 401:243.
Alternate Names
Entrez Gene IDs
Gene Symbol
UniProt
Additional Caronte Products
Product Documents for Chicken Caronte Alexa Fluor™ Plus 555‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Chicken Caronte Alexa Fluor™ Plus 555‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
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