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Chicken Caronte Biotinylated Antibody

Catalog #: BAF1051 1 Review Datasheet / COA / SDS
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BAF1051

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Chicken Caronte Biotinylated Antibody Summary

Species Reactivity
Chicken
Specificity
Detects chicken Caronte in Western blots. In this format, less than 1% cross-reactivity with recombinant human DAN and recombinant mouse Gremlin is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant chicken Caronte
Asp16-Asn272
Accession # NP_990154
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Chicken Caronte Fc Chimera (Catalog # 1051-CA)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Caronte

Chicken Caronte, the ortholog of mammalian Cerberus, is a member of the Cerberus/DAN family of secreted glycoproteins. There are at least 5 Dan Domain (DAND) family members including DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), Cerberus (DAND4), and Coco (DAND5). Caronte is expressed in the left paraxial mesoderm and is the molecule responsible for transducing left-sided positional information from the node to the periphery of the lateral plate mesoderm (LPM) during chicken embryonic development. Caronte functions as a BMP antagonist, inducing Nodal and downstream genes in the LPM by interfering with the repressive activity of bilaterally-produced BMPs. In addition, antagonism of BMPs by Caronte induces the expression of the Lefty gene in the midline. Caronte binds both BMP-4 and BMP-7 in immunoprecipitation experiments.

References
  1. Pearce, J. et al. (1999) Dev. Biol. 209:98.
  2. Yokouchi, Y. et al. (1999) Cell. 98:573.
  3. King, T. and N. Brown (1999) Nature 401:222.
  4. Ahu, L. et al. (1999) Curr. Biol. 9:931.
  5. Rodriguez-Esteban, C. et al. (1999) Nature 401:243.
Entrez Gene IDs
395623 (Chicken)
Alternate Names
Caronte; Chicken Caronte

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Chicken Caronte Biotinylated Antibody
By Anonymous on 02/18/2021
Application: B/N Sample Tested: Recombinant protein Species: Human
Block/Neutralize Chicken Caronte Biotinylated Antibody BAF1051