Catalog Number: 4109
Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Biological Activity
Antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
    Jiang et al.
    Biomed.Pharmacother., 2010;64:609
  2. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
    Sasaki et al.
    BMC Cancer, 2010;10:370
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