Chloroquine diphosphate

Catalog # Availability Size / Price Qty
Chloroquine diphosphate | CAS No. 50-63-5 | Antimalarials
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Description: Antimalarial; inhibits apoptosis and autophagy

Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

Purity: ≥99%

Product Details
Citations (2)

Biological Activity

Chloroquine diphosphate is an antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM).

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
    Jiang et al.
    Biomed.Pharmacother., 2010;64:609
  2. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
    Sasaki et al.
    BMC Cancer, 2010;10:370
  3. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
    Wang et al.
    Cell Research, 2020;30
  4. Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling.
    Tietze et al.
    Biochem.Biophys.Res.Commun., 1980;93:1

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Citations for Chloroquine diphosphate

The citations listed below are publications that use Tocris products. Selected citations for Chloroquine diphosphate include:

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