Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Biological ActivityAntimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Jiang et al.
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
Sasaki et al.
BMC Cancer, 2010;10:370
Citations for Chloroquine diphosphate
The citations listed below are publications that use Tocris products. Selected citations for Chloroquine diphosphate include:
2 Citations: Showing 1 - 2
Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy.
Authors: Tong Et al.
J Cell Mol Med 2018;
Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613
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