Chloroquine diphosphate
Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Purity: ≥99%
Biological Activity
Antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Jiang et al.
Biomed.Pharmacother., 2010;64:609 -
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
Sasaki et al.
BMC Cancer, 2010;10:370
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Citations for Chloroquine diphosphate
The citations listed below are publications that use Tocris products. Selected citations for Chloroquine diphosphate include:
2 Citations: Showing 1 - 2
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Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy.
Authors: Tong Et al.
J Cell Mol Med 2018;
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Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613
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