CID 16020046

Catalog # Availability Size / Price Qty
4959/5
4959/25
Cat.No. 4959 - CID 16020046 | C25H19N3O4 | CAS No. 834903-43-4
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Description: Selective GPR55 antagonist

Chemical Name: 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity

Selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.

Technical Data

M.Wt:
425.44
Formula:
C25H19N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
834903-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for CID 16020046

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