CID 755673

  ( 11 citations )    
Product Datasheet
Catalog Number:3327
Chemical Name:2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.
Technical Data
  • M.Wt:
    217.22
  • Formula:
    C12H11NO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    521937-07-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CID 755673 include:

11 Citations: Showing 1 - 10
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  1. GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
    Authors: Xu Et al.
    Biochem Biophys Res Commun  2015;26:874
  2. Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
    Authors: Chen and Kan
    Biochim Biophys Acta  2015;1853:2662
  3. Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.
    Authors: Rezaee Et al.
    J Virol  2013;87:11088
  4. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
    Authors: Kienzle Et al.
    Mol Biol Cell  2013;24:222
  5. Sphingomyelin synthases regulate protein trafficking and secretion.
    Authors: Subathra Et al.
    PLoS One  2011;6:e23644
  6. Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
    Authors: Dokas Et al.
    Neuropharmacology  2011;61:12
  7. Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
    Authors: Qureshi Et al.
    PLoS One  2011;5:e15587
  8. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.
    Authors: Zheng Et al.
    Mol Cell Biol  2011;31:710
  9. Protein kinase D regulates cofilin activity through p21-activated kinase 4.
    Authors: Spratley Et al.
    Sci Signal  2011;286:34254
  10. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor.
    Authors: Bhattacharya Et al.
    Blood  2011;118:4179
  11. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.
    Authors: Torres-Marquez Et al.
    J Biol Chem  2010;391:63
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