Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Biological ActivitySelective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone.
Sharlow et al.
Citations for CID 755673
The citations listed below are publications that use Tocris products. Selected citations for CID 755673 include:
12 Citations: Showing 1 - 10
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Authors: Zhang Et al.
J Exp Med 2017;214:2671
GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
Authors: Xu Et al.
Biochem Biophys Res Commun 2015;26:874
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
Authors: Chen and Kan
Biochim Biophys Acta 2015;1853:2662
Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.
Authors: Rezaee Et al.
J Virol 2013;87:11088
PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
Authors: Kienzle Et al.
Mol Biol Cell 2013;24:222
Sphingomyelin synthases regulate protein trafficking and secretion.
Authors: Subathra Et al.
PLoS One 2011;6:e23644
Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
Authors: Dokas Et al.
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
Authors: Qureshi Et al.
PLoS One 2011;5:e15587
Ligand-stimulated downregulation of the alpha IF. receptor: role of protein kinase D2.
Authors: Zheng Et al.
Mol Cell Biol 2011;31:710
Protein kinase D regulates cofilin activity through p21-activated kinase 4.
Authors: Spratley Et al.
Sci Signal 2011;286:34254
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor.
Authors: Bhattacharya Et al.
CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.
Authors: Torres-Marquez Et al.
J Biol Chem 2010;391:63
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for CID 755673
There are currently no reviews for this product. Be the first to review CID 755673 and earn rewards!
Have you used CID 755673?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image