CID 755673

Tocris Bioscience | Catalog # 3327

Selective protein kinase D inhibitor
Tocris Bioscience

Key Product Details

Description

Selective protein kinase D inhibitor
View all Protein Kinase D Inhibitors »

Product Description

CID 755673 is a selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Product Specifications for CID 755673

Molecular Weight

217.22

Formula

C12H11NO3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

CAS Number

521937-07-5

PubChem ID

755673

InChI Key

AACFPJSJOWQNBN-UHFFFAOYSA-N

SMILES

OC1=CC2=C(OC3=C2CCCNC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.72 100

Preparing Stock Solutions for CID 755673

The following data is based on the product molecular weight 217.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.60 mL 23.02 mL 46.04 mL
5 mM 0.92 mL 4.60 mL 9.21 mL
10 mM 0.46 mL 2.30 mL 4.60 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

Product Documents for CID 755673

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CID 755673

For research use only

Customer Reviews for CID 755673 (1)

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  • Effect of CID 755673 on PKD has been under observation.
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 01/16/2020
    Effect of CID 755673 on PKD has been under observation. Changes in the FRET ratio from COS-7 cells expressing the kinase activity reporter, DKAR, following activation of endogenous PKD (light blue diamonds) or overexpressed PKD (dark blue diamonds) via 200 nM PDBu treatment and subsequent PKD inhibition with the non-competitive CID 755673 (50 μM).
    CID 755673 3327

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