Catalog Number: 3327
Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Biological Activity
Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.
Technical Data
  • M.Wt:
    217.22
  • Formula:
    C12H11NO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    521937-07-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone.
    Sharlow et al.
    J.Biol.Chem., 2008;283:33516
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CID 755673 include:

8 Citations: Showing 1 - 8
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  1. GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
    Authors: Xu Et al.
    Biochem Biophys Res Commun 2015;26:874
  2. Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.
    Authors: Rezaee Et al.
    J Virol 2013;87:11088
  3. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
    Authors: Kienzle Et al.
    Mol Biol Cell 2013;24:222
  4. Sphingomyelin synthases regulate protein trafficking and secretion.
    Authors: Subathra Et al.
    PLoS One 2011;6:e23644
  5. Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
    Authors: Qureshi Et al.
    PLoS One 2011;5:e15587
  6. Protein kinase D regulates cofilin activity through p21-activated kinase 4.
    Authors: Spratley Et al.
    Sci Signal 2011;286:34254
  7. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor.
    Authors: Bhattacharya Et al.
    Blood 2011;118:4179
  8. CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.
    Authors: Torres-Marquez Et al.
    J Biol Chem 2010;391:63
Tocris Small Molecules
Description Application Cat# Citations Images  

kb NB 142-70

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