CID 755673

Catalog # Availability Size / Price Qty
CID 755673 | CAS No. 521937-07-5 | Protein Kinase D Inhibitors
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Description: Selective protein kinase D inhibitor

Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products

Biological Activity

CID 755673 is a selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone.
    Sharlow et al.
    J.Biol.Chem., 2008;283:33516

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Citations for CID 755673

The citations listed below are publications that use Tocris products. Selected citations for CID 755673 include:

12 Citations: Showing 1 - 10

  1. Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
    Authors: Zhang Et al.
    J Exp Med  2017;214:2671
  2. GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
    Authors: Xu Et al.
    Biochem Biophys Res Commun  2015;26:874
  3. Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
    Authors: Chen and Kan
    Biochim Biophys Acta  2015;1853:2662
  4. Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.
    Authors: Rezaee Et al.
    J Virol  2013;87:11088
  5. PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
    Authors: Kienzle Et al.
    Mol Biol Cell  2013;24:222
  6. Sphingomyelin synthases regulate protein trafficking and secretion.
    Authors: Subathra Et al.
    PLoS One  2011;6:e23644
  7. Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
    Authors: Dokas Et al.
    Neuropharmacology  2011;61:12
  8. Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
    Authors: Qureshi Et al.
    PLoS One  2011;5:e15587
  9. Ligand-stimulated downregulation of the alpha IF. receptor: role of protein kinase D2.
    Authors: Zheng Et al.
    Mol Cell Biol  2011;31:710
  10. Protein kinase D regulates cofilin activity through p21-activated kinase 4.
    Authors: Spratley Et al.
    Sci Signal  2011;286:34254


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