Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Biological ActivitySelective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone.
Sharlow et al.
Citations for CID 755673
The citations listed below are publications that use Tocris products. Selected citations for CID 755673 include:
12 Citations: Showing 1 - 10
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Authors: Zhang Et al.
J Exp Med 2017;214:2671
GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
Authors: Xu Et al.
Biochem Biophys Res Commun 2015;26:874
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
Authors: Chen and Kan
Biochim Biophys Acta 2015;1853:2662
Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption.
Authors: Rezaee Et al.
J Virol 2013;87:11088
PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
Authors: Kienzle Et al.
Mol Biol Cell 2013;24:222
Sphingomyelin synthases regulate protein trafficking and secretion.
Authors: Subathra Et al.
PLoS One 2011;6:e23644
Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
Authors: Dokas Et al.
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
Authors: Qureshi Et al.
PLoS One 2011;5:e15587
Ligand-stimulated downregulation of the alpha IF. receptor: role of protein kinase D2.
Authors: Zheng Et al.
Mol Cell Biol 2011;31:710
Protein kinase D regulates cofilin activity through p21-activated kinase 4.
Authors: Spratley Et al.
Sci Signal 2011;286:34254
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor.
Authors: Bhattacharya Et al.
CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.
Authors: Torres-Marquez Et al.
J Biol Chem 2010;391:63
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Effect of CID 755673 on PKD has been under observation. Changes in the FRET ratio from COS-7 cells expressing the kinase activity reporter, DKAR, following activation of endogenous PKD (light blue diamonds) or overexpressed PKD (dark blue diamonds) via 200 nM PDBu treatment and subsequent PKD inhibition with the non-competitive CID 755673 (50 μM).