kb NB 142-70
Chemical Name: 9-Hydroxy-3,4-dihydro-2H--benzothiolo[2,3-f][1,4]thiazepin-5-one
Biological Activitykb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
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PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.
Ni et al.
PLoS ONE, 2013;9:e73149
Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility.
LaValle et al.
BMC Chemical Biology, 2010;10:5
Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D.
Bravo-Altamirano et al.
ACS Med.Chem.Lett., 2011;2:154
Citations for kb NB 142-70
The citations listed below are publications that use Tocris products. Selected citations for kb NB 142-70 include:
3 Citations: Showing 1 - 3
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Authors: Zhang Et al.
J Exp Med 2017;214:2671
Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.
Authors: Xiong Et al.
Sci Rep 2016;6:34079
A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.
Authors: Weber Et al.
BMC Syst Biol 2015;9:9
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