Catalog Number: 3962
Chemical Name: 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
Biological Activity
Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
Technical Data
  • M.Wt:
    251.32
  • Formula:
    C11H9NO2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1233533-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.
    Ni et al.
    PLoS One, 2013;8:e73149
  2. Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility.
    LaValle et al.
    BMC Chemical Biology, 2010;10:5
  3. Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D.
    Bravo-Altamirano et al.
    ACS Med.Chem.Lett., 2011;2:154
Citations:

The citations listed below are publications that use Tocris products. Selected citations for kb NB 142-70 include:

1 Citations: Showing 1 - 1

  1. A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.
    Authors: Weber Et al.
    BMC Syst Biol 2015;9:9
Tocris Small Molecules
Description Application Cat# Citations Images  

CID 755673

3327 8  
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