kb NB 142-70
Chemical Name: 9-Hydroxy-3,4-dihydro-2H--benzothiolo[2,3-f][1,4]thiazepin-5-one
Biological ActivitySelective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.
Ni et al.
PLoS ONE, 2013;9:e73149
Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility.
LaValle et al.
BMC Chemical Biology, 2010;10:5
Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D.
Bravo-Altamirano et al.
ACS Med.Chem.Lett., 2011;2:154
Citations for kb NB 142-70
The citations listed below are publications that use Tocris products. Selected citations for kb NB 142-70 include:
3 Citations: Showing 1 - 3
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Authors: Zhang Et al.
J Exp Med 2017;214:2671
Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.
Authors: Xiong Et al.
Sci Rep 2016;6:34079
A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.
Authors: Weber Et al.
BMC Syst Biol 2015;9:9
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for kb NB 142-70
There are currently no reviews for this product. Be the first to review kb NB 142-70 and earn rewards!
Have you used kb NB 142-70?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image