kb NB 142-70

  ( 2 citations )    
Product Datasheet
Catalog Number:3962
Chemical Name:9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
Product Details
Citations (2)
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Biological Activity
Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
Technical Data
  • M.Wt:
    251.32
  • Formula:
    C11H9NO2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    1233533-04-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for kb NB 142-70 include:

2 Citations: Showing 1 - 2
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  1. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.
    Authors: Xiong Et al.
    Sci Rep  2016;6:34079
  2. A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.
    Authors: Weber Et al.
    BMC Syst Biol  2015;9:9

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