CILP-1 Antibody

Novus Biologicals | Catalog # NB100-41106

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Rat

Predicted:

Canine (100%), Human (100%), Mouse (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all CILP-1 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NYRRTDHEDPRVK corresponding to internal region according to NP_003604.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CILP-1 Antibody

Western Blot: CILP-1 Antibody [NB100-41106]

Western Blot: CILP-1 Antibody [NB100-41106]

Western Blot: CILP-1 Antibody [NB100-41106] - (0.03ug/ml) staining of rat spinal cord lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for CILP-1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:128000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 150 kDa band observed in rat spinal cord lysates (calculated MW of 133 kDa band according to human NP_003604.2 and of 132 kDa band according to rat NP_001101631.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CILP-1

CILP, Cartilage Intermediate Layer Protein, is specifically expressed in the articular cartilage intermediate layer (it cannot be found in the superficial nor in the deepest layers) and is involved in scaffolding. Overexpression of this protein may lead to impairment of chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Antibodies against CILP are detected in patients with early-stage knee osteoarthritis and defects in this gene may be a cause of susceptibility to lumbar disk disease.

Long Name

Cartilage Intermediate Layer Protein 1

Alternate Names

CILP, CILP1

Entrez Gene IDs

8483 (Human); 214425 (Mouse); 315761 (Rat)

Gene Symbol

CILP

UniProt

NP_003604.2 (Human)

Additional CILP-1 Products

Product Documents for CILP-1 Antibody

Certificate of Analysis

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Product Specific Notices for CILP-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for CILP-1 Antibody

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