Clozapine N-oxide dihydrochloride

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Clozapine N-oxide dihydrochloride | CAS No. 2250025-93-3 | DREADD Activators
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Description: Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
Alternative Names: CNO (water-soluble)

Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride

Purity: ≥99%

Product Details
Citations (21)
Supplemental Products

Biological Activity

Clozapine N-oxide dihydrochloride is a water-soluble salt of Clozapine N-oxide (Cat. No.4936). Activator of muscarinic DREADDs. Clozapine N-oxide dihydrochloride exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Clozapine N-oxide dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Clozapine N-oxide dihydrochloride include:

21 Citations: Showing 1 - 10

  1. Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice.
    Authors: Laura E Et al.
    Elife  2023;12
  2. Gestational ethanol exposure impairs motor skills in female mice through dysregulated striatal dopamine and acetylcholine function.
    Authors: David M Et al.
    Neuropsychopharmacology  2023;
  3. Prefrontal feature representations drive memory recall.
    Authors: Andrea Et al.
    Nature  2022;608:153-160
  4. A brainstem circuit for nausea suppression.
    Authors: Frank Et al.
    Cell Rep  2022;39:110953
  5. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.
    Authors: Domokos Et al.
    J Exp Med  2022;219
  6. Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission.
    Authors: Yuval Et al.
    Neuropharmacology  2022;205:108918
  7. A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice.
    Authors: Gilberto Et al.
    Nat Commun  2022;13:5944
  8. Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway.
    Authors: Qiang Et al.
    Proc Natl Acad Sci U S A  2022;119:e2203503119
  9. Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex.
    Authors: Jean-Pierre Et al.
    Cell Rep  2021;37:110035
  10. Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress.
    Authors: Wei Et al.
    Cell Rep  2021;34:108874
  11. Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice.
    Authors: Hye-Jin Et al.
    Nat Commun  2021;12:6682
  12. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.
    Authors: Stephen D Et al.
    Neuron  2021;109:461-472.e5
  13. Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex.
    Authors: Benjamin R Et al.
    Elife  2021;10
  14. Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2.
    Authors: Boender Et al.
    Biol Psychiatry  2020;89:1045
  15. The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
    Authors: Sheahan Et al.
    J Neurosci  2020;40:8816
  16. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.
    Authors: Henry A Et al.
    Cell  2020;183:1986-2002.e26
  17. Glutamatergic projections from homeostatic to hedonic brain nuclei regulate intake of highly palatable food.
    Authors: Jonathan D Et al.
    Sci Rep  2020;10:22093
  18. Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an a-synuclein based rat model for Parkinson's disease.
    Authors: Torre-Muruzabal Et al.
    Acta Neuropathol Commun  2019;7:160
  19. The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice.
    Authors: Chang Et al.
    Cell Rep  2019;28:1195
  20. PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia.
    Authors: Khodai Et al.
    Front Endocrinol (Lausanne)  2018;9:632
  21. Thalamic reticular control of local sleep in mouse sensory cortex.
    Authors: Fernandez Et al.
    Elife  2018;7


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