Clozapine N-oxide dihydrochloride
Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Purity: ≥99%
Biological Activity
Clozapine N-oxide dihydrochloride is a water-soluble salt of Clozapine N-oxide (Cat. No.4936). Activator of muscarinic DREADDs. Clozapine N-oxide dihydrochloride exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.
Nakajima et al.
Nat. Commun., 2016;8:10268 -
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Ambruster et al.
Proc.Natl.Acad.Sci.U.S.A., 2007;104:5163 -
LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
Zaman et al.
J.Neurosci., 2014;34:140 -
DREADDs for Neuroscientists.
Roth et al.
Neuron, 2016;89:683 -
A comparative study of the pharmacokinetics of cloz. N-oxide and cloz. N-oxide hydrochloride salt in rhesus macaques.
Allen et al.
J.Pharmacol.Exp.Ther., 2019;368:199 -
The involvement of CYP1A2 and CYP3A4 in the metabolism of cloz.
Eiermann et al.
Br.J.Clin.Pharmacol., 1997;44:439 -
Chemogenetics revealed: DREADD occupancy and activation via converted cloz.
Gomez et al.
Science, 2017;357:503
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Citations for Clozapine N-oxide dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Clozapine N-oxide dihydrochloride include:
6 Citations: Showing 1 - 6
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Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2.
Authors: Boender Et al.
Biol Psychiatry 2020;89:1045
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The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
Authors: Sheahan Et al.
J Neurosci 2020;40:8816
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Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an a-synuclein based rat model for Parkinson's disease.
Authors: Torre-Muruzabal Et al.
Acta Neuropathol Commun 2019;7:160
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The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice.
Authors: Chang Et al.
Cell Rep 2019;28:1195
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PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia.
Authors: Khodai Et al.
Front Endocrinol (Lausanne) 2018;9:632
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Thalamic reticular control of local sleep in mouse sensory cortex.
Authors: Fernandez Et al.
Elife 2018;7
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