Clozapine N-oxide dihydrochloride

Tocris Bioscience | Catalog # 6329

Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
Tocris Bioscience

Key Product Details

Description

Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)

Alternative Names

CNO (water-soluble)
View all DREADD Activators »

Product Description

Clozapine N-oxide dihydrochloride is a water-soluble salt of Clozapine N-oxide (Cat. No.4936). Activator of muscarinic DREADDs. Clozapine N-oxide dihydrochloride exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.

Product Specifications for Clozapine N-oxide dihydrochloride

Molecular Weight

415.74

Formula

C18H19ClN4O.2HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride

CAS Number

2250025-93-3

PubChem ID

137187247

InChI Key

MBRGKRXDVKTUPT-UHFFFAOYSA-N

SMILES

ClC(C=C1)=CC2=C1NC(C=CC=C3)=C3C(N4CC[N+](C)([O-])CC4)=N2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.57 100
DMSO 41.57 100

Preparing Stock Solutions for Clozapine N-oxide dihydrochloride

The following data is based on the product molecular weight 415.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.05 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.20 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 100 publications citing the usage of this product.

Product Documents for Clozapine N-oxide dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Clozapine N-oxide dihydrochloride

For research use only

Citations for Clozapine N-oxide dihydrochloride

Customer Reviews for Clozapine N-oxide dihydrochloride (1)

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  • Great H2O soluble version of CNO
    Name: Melanie Pina
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/23/2019
    Great water soluble version that worked beautifully in my hands. Used to stimulate virally-expressed hM4Di for behavioral neuroscience applications. CNO-induced activation of hM4Di significantly inhibited neuronal activation as confirmed via c-Fos staining.
    Clozapine N-oxide dihydrochloride 6329

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