CLP 290

Key Product Details

Product Description

CLP 290 is a K⁺/Cl^- Cotransporter 2 (KCC2) activator. Activates spinal inhibitory interneurons, restores physiological neuronal activity in the spinal cord and induces functional recovery in a mouse model of spinal cord injury. Also decreases blood vasopressin and glucose levels in mice with Streptozotocin (Cat. No. 1621) induced diabetes mellitus. Orally bioavailable prodrug of CLP 257 (Cat. No.5242).

Product Specifications for CLP 290

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CLP 290

The following data is based on the product molecular weight 404.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.94 mL	24.72 mL	49.45 mL
2.5 mM	0.99 mL	4.94 mL	9.89 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
25 mM	0.10 mL	0.49 mL	0.99 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kim Long-term ionic plasticity of GABAergic signalling in the hypothalamus. J.Neuroendocrinol. 2019 PMID: 31166034
• Chen Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations. Cell 2018 PMID: 30033363
• Gagnon Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 2013 PMID: 24097188

Product Documents for CLP 290