Coagulation Factor XIV/Protein C Antibody (PC 7) [DyLight 405]

Novus Biologicals | Catalog # NBP1-05113V

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # PC 7
View all Coagulation Factor XIV/Protein C Primary Antibodies »

Product Specifications

Immunogen

Recombinant human activated protein C

Epitope

Specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin.

Reactivity Notes

Chemical

Specificity

Has specificity for a conformation dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin. No reaction is seen to non-complexed alpha1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Coagulation Factor XIV/Protein C Antibody (PC 7) [DyLight 405]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Coagulation Factor XIV/Protein C

Protein C is a vitamin K-dependent serine protease that is produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa inhibiting blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentration in human plasma is approximately 1-3 ng/ml while the concentration of the proenzyme is approximately 3 ug/mL due to the very fast turnover.

Long Name

Vitamin K-dependent Protein C

Alternate Names

Autoprothrombin IIA, PROC, Protein C

Gene Symbol

PROC

Additional Coagulation Factor XIV/Protein C Products

Product Documents for Coagulation Factor XIV/Protein C Antibody (PC 7) [DyLight 405]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Coagulation Factor XIV/Protein C Antibody (PC 7) [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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Associated Pathways

Blood Coagulation Signaling Pathways Blood Coagulation Signaling Pathway Thumbnail