Biological ActivityCOG 133 is an apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
(Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
Gay et al.
Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.
Li et al.
N-MthD.-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
Sheng et al.
Citation for COG 133
The citations listed below are publications that use Tocris products. Selected citations for COG 133 include:
1 Citation: Showing 1 - 1
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
Authors: Tavazoie Et al.
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