COG 133

   
Product Datasheet
Catalog Number:3405
Alternate Names:apoE(133-149)
Chemical Name:
Product Details
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Biological Activity
Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
Technical Data
  • M.Wt:
    2169.73
  • Formula:
    C97H181N37O19
  • Sequence:
    LRVRLASHLRKLRKRLL

    (Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    514200-66-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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