Catalog Number: 3405
Alternate Names: apoE(133-149)
Biological Activity
Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
Technical Data
  • M.Wt:
    2169.73
  • Formula:
    C97H181N37O19
  • Sequence:
    LRVRLASHLRKLRKRLL

    (Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    514200-66-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
    Gay et al.
    J.Pharmacol.Exp.Ther., 2006;316:835
  2. Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.
    Li et al.
    J.Pharmacol.Exp.Ther., 2006;318:956
  3. N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
    Sheng et al.
    Neuropharmacology, 2008;55:204

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