Q: I am interested in purchasing the following antibody: catalog # NB120-11879 Complement C5 Ab. In which epitope its been raised against? What volume do you get out of 0.05mg? Also, what is its cost and does it work on ELISA?

A: NB120-11879 is not epitope mapped but it is known that it reacts with an epitope on C5 and on C5b. The concentration is 0.1 mg/mL which is a volume of 500 uL and it has not yet been validated for use in ELISA. Regarding the price of this product, please use our website to select your country, which will allow you to view the country specific pricing, availability and technical support information.

Complement C5 Antibody (568)

Novus Biologicals | Catalog # NB120-11879

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2A Clone # 568

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Product Specifications

Immunogen

Unfortunately, this information is considered to be commercially sensitive.

Specificity

This reacts with an epitope on C5 and on C5b.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Description

Novus Biologicals Mouse Complement C5 Antibody (568) (NB120-11879) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.

Applications for Complement C5 Antibody (568)

Application

Recommended Usage

Western Blot

1:100-1:2000

Application Notes

WB: 188.3 kDa. Optimal dilutions/concentrations should be determined by the end user.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement C5

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa). C5 occurs in plasma at about 75mg/L. It is activated via either the classical or the alternative complement pathway, by protoelytic cleavage of C5a (11.5kDa) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b,initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.

Alternate Names

anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5, complement C5, complement component 5, CPAMD4MGC142298, FLJ17816, FLJ17822

Entrez Gene IDs

727 (Human)

Gene Symbol

Additional Complement C5 Products

Product Documents for Complement C5 Antibody (568)

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Certificate of Analysis

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Product Specific Notices for Complement C5 Antibody (568)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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