Concanamycin A

Name: Concanamycin A
Brand: Tocris Bioscience
SKU: 2656
Price: 211 USD
Availability: InStock

Tocris Bioscience | Catalog # 2656

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Citations (32)

Product Documents

H+-ATPase (vacuolar) inhibitor

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

H+-ATPase (vacuolar) inhibitor

Alternative Names

Folimycin

View all H+-ATPase Inhibitors »

Product Description

Concanamycin A is a specific inhibitor of V-type (vacuolar) H⁺-ATPase that displays > 2000-fold selectivity over other H⁺-ATPases (IC₅₀ values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H⁺-ATPases and porcine P-type Na⁺,K⁺-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Product Specifications for Concanamycin A

Molecular Weight

866.09

Formula

C₄₆H₇₅NO₁₄

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

CAS Number

80890-47-7

PubChem ID

6438151

InChI Key

DJZCTUVALDDONK-HQMSUKCRSA-N

SMILES

O=C1O[C@@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](/C=C/C)[C@@H](C)[C@H](O[C@]3([H])O[C@H](C)[C@@H](OC(N)=O)[C@H](O)C3)C2)([H])[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Muroi Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus. Cell Struct.Function.
Nishihara Specific inhibitors of vacuolar type H⁺-ATPases induce apoptotic cell death. Biochem.Biophy.Res.Comm.
Hong Nitric oxide production by the vacuolar-type (H⁺)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. J.Pharmacol.Exp.Ther. 2006 PMID: 16895977

Product Documents for Concanamycin A

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Product Specific Notices for Concanamycin A

For research use only

Related Research Areas

Autophagy

Citations for Concanamycin A

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