Chemical Name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
Biological ActivityConcanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells.
Hong et al.
Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus.
Muroi et al.
Cell Struct.Function., 1993;18:139
Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death.
Nishihara et al.
Citations for Concanamycin A
The citations listed below are publications that use Tocris products. Selected citations for Concanamycin A include:
2 Citations: Showing 1 - 2
Recruitment of LC3 to damaged Golgi apparatus.
Authors: Gomes-da-Silva Et al.
Cell Death Differ 2019;26:1467
Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells.
Authors: Chabaud Et al.
Nat Commun 2015;6:7526
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