Concanamycin A

Catalog # Availability Size / Price Qty
2656/10U
Concanamycin A | CAS No. 80890-47-7 | H+-ATPase Inhibitors
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Description: H+-ATPase (vacuolar) inhibitor
Alternative Names: Folimycin

Chemical Name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

Purity: ≥90%

Product Details
Citations (2)
Reviews

Biological Activity

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Technical Data

M.Wt:
866.09
Formula:
C46H75NO14
Solubility:
Soluble in DMSO
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
80890-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells.
    Hong et al.
    J.Pharmacol.Exp.Ther., 2006;319:672
  2. Folimycin (Concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitus virus before arrival to the golgi apparatus.
    Muroi et al.
    Cell Struct.Function., 1993;18:139
  3. Specific inhibitors of vacuolar type H+-ATPases induce apoptotic cell death.
    Nishihara et al.
    Biochem.Biophy.Res.Comm., 1995;212:255

Product Datasheets

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Citations for Concanamycin A

The citations listed below are publications that use Tocris products. Selected citations for Concanamycin A include:

2 Citations: Showing 1 - 2

  1. Recruitment of LC3 to damaged Golgi apparatus.
    Authors: Gomes-da-Silva Et al.
    Cell Death Differ  2019;26:1467
  2. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells.
    Authors: Chabaud Et al.
    Nat Commun  2015;6:7526

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