Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro
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The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli.
Gumport and Edelhei et al.
Antifungal activity of 3'-deoxyadenosine (cordycepin).
Sugar and McCaffrey
Antimicrob.Agents Chemother., 1998;42:1424
Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.
Kodama et al.