Cordycepin
Chemical Name: 3'-Deoxyadenosine
Biological Activity
Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli.
Gumport and Edelhei et al.
Biochemistry, 1976;15:2804 -
Antifungal activity of 3'-deoxyadenosine (cordycepin).
Sugar and McCaffrey
Antimicrob.Agents Chemother., 1998;42:1424 -
Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.
Kodama et al.
Biochem.Pharmacol., 2000;59:273
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Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
