CP 100356 hydrochloride

Catalog # Availability Size / Price Qty
CP 100356 hydrochloride | CAS No. 142715-48-8 | Multidrug Transporter Inhibitors
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Description: P-gp inhibitor

Chemical Name: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC50 > 50 μM).

Technical Data

Soluble to 20 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citation for CP 100356 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CP 100356 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Calcium and P-glycoprotein independent synergism between schweinfurthins and vera.
    Authors: Sheehy Et al.
    Acta Neuropathol Commun  2015;16:1259


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