CPI 203

Tocris Bioscience | Catalog # 5331

BET bromodomain inhibitor; arrests cell cycle at G1 phase
Tocris Bioscience

Key Product Details

Description

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Alternative Names

TEN 010
View all Bromodomain Inhibitors »

Product Description

CPI 203 is a BET bromodomain inhibitor. Downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Also enhances fibroblast reprogramming to hiPSCs at low concentration. Orally bioavailable.

Product Specifications for CPI 203

Molecular Weight

399.90

Formula

C19H18ClN5OS

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

CAS Number

1446144-04-2

PubChem ID

71291068

InChI Key

QECMENZMDBOLDR-AWEZNQCLSA-N

SMILES

NC(C[C@@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.99 100
Ethanol 4 10

Preparing Stock Solutions for CPI 203

The following data is based on the product molecular weight 399.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.50 mL 12.50 mL 25.01 mL
5 mM 0.50 mL 2.50 mL 5.00 mL
10 mM 0.25 mL 1.25 mL 2.50 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for CPI 203

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CPI 203

For research use only

Customer Reviews for CPI 203 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used CPI 203?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Reprogramming media with CPI203
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ipsc
    Verified Customer | Posted 02/23/2020
    50 nM
    CPI 203 5331

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All