CPI 203

Catalog # Availability Size / Price Qty
5331/10
CPI 203 | CAS No. 1446144-04-2 | Bromodomain Inhibitors
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Description: BET bromodomain inhibitor; arrests cell cycle at G1 phase
Alternative Names: TEN 010

Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

CPI 203 is a BET bromodomain inhibitor. Downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Also enhances fibroblast reprogramming to hiPSCs at low concentration. Orally bioavailable.

Technical Data

M.Wt:
399.9
Formula:
C19H18ClN5OS
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1446144-04-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for CPI 203

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Reprogramming media with CPI203
By Anonymous on 02/23/2020
Application: Species: Mouse

50 nM

PMID: 27653680

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