Active metabolite of CPT-11
(Cat. No. 2688) that inhibits DNA topoisomerase I (IC50
values are 0.74 and 1.9 μ
M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50
values are 0.077 and 1.3 μ
M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50
values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
Kawato et al.
Cancer Res., 1991;51:4187
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Gao et al.
Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.
Koizumi et al.
Cancer Res., 2006;66:10048
The citations listed below are publications that use Tocris products. Selected citations for SN 38 include:
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