Catalog Number: 2684
Alternate Names: 7-Ethyl-10-hydroxycamptothecin
Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Biological Activity
Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
Technical Data
  • M.Wt:
    392.4
  • Formula:
    C22H20N2O5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    86639-52-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
    Kawato et al.
    Cancer Res., 1991;51:4187
  2. Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
    Gao et al.
    Bioorg.Med.Chem.Lett., 2005;15:3233
  3. Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.
    Koizumi et al.
    Cancer Res., 2006;66:10048
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SN 38 include:

2 Citations: Showing 1 - 2
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  1. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis.
    Authors: Vétillard Et al.
    Exp Neurol 2015;6:43342
  2. Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1.
    Authors: Jonchère Et al.
    Oncotarget 2015;6:409

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