CrkL [p Tyr207] Antibody

Novus Biologicals | Catalog # NBP3-13318

Novus Biologicals
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all CrkL Primary Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Tyr207 of human CrkL. The exact sequence is proprietary.

Modification

p Tyr 207

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Centrifuge briefly prior to opening.

Scientific Data Images for CrkL [p Tyr207] Antibody

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with CrkL (phospho Tyr207) antibody (NBP3-13318) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318] - Untreated (-) and treated (+) K562 whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with CrkL (phospho Tyr207) antibody (NBP3-13318) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318]

Western Blot: CrkL [p Tyr207] Antibody [NBP3-13318] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with CrkL (phospho Tyr207) antibody (NBP3-13318) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.

Applications for CrkL [p Tyr207] Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CrkL

CrkL is a widely-expressed 39 kD adaptor protein that belongs to the Crk protein family and is abundantly expressed in cells of hematopoetic origin. Through its SH2 and SH3 domains CrkL initiates interactions with numerous downstream proteins such as CBL, Cas, Paxillin, C3G, SOS, PI3K, c-Abl and BCR/Abl. It is involved in processes such as adhesion, migration and immune responses. Furthermore, CrkL plays an essential role in Chronic Myelogenous Leukemia and is constitutively phosphorylated by the Bcr-Abl kinase in this disease.

Long Name

V-Crk Sarcoma Virus CT10 Oncogene Homolog-like Protein

Alternate Names

crk-like protein, pCRKL, v-crk avian sarcoma virus CT10 oncogene homolog-like, v-crk sarcoma virus CT10 oncogene homolog (avian)-like

Gene Symbol

CRKL

Additional CrkL Products

Product Documents for CrkL [p Tyr207] Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CrkL [p Tyr207] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins
Interferons

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