Biological ActivityCXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.
(Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.
Kwong et al.
Mol.Cancer Ther., 2009;8:1893
The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells.
Faber et al.
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model.
Hassan et al.
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