Catalog Number: 5130
Biological Activity
CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.
Technical Data
  • M.Wt:
    1927.27
  • Formula:
    C86H147N27O23
  • Sequence:
    KGVSLSYRK KGVSLSYR*

    (Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)

  • Storage:
    Store at -20°C
  • CAS No:
    1030384-98-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.
    Kwong et al.
    Mol.Cancer Ther., 2009;8:1893
  2. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.
    Hassan et al.
    Int.J.Cancer., 2011;129:225
  3. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells.
    Faber et al.
    J.Biomed.Biotechnol., 2007;2007:26065

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