Cyclic analog of pifithrin-α
(Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50
= 2.01 μ
M). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
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All Tocris products are intended for laboratory research use only.
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α.
Barchechath et al.
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.
Pietrancosta et al.
Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.
Zuco and Zunino