Cyclic Pifithrin-α hydrobromide

Catalog # Availability Size / Price Qty
3843/10
3843/50
p53 Inhibitors Small Molecule
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Description: p53 inhibitor
Alternative Names: Pifithrin-β

Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Technical Data

M.Wt:
349.29
Formula:
C16H16N2S.HBr
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
511296-88-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Cyclic Pifithrin-α hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Cyclic Pifithrin-α hydrobromide include:

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