Catalog Number: 3843
Alternate Names: Pifithrin-β
Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
Biological Activity
Cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α.
    Barchechath et al.
    J.Med.Chem., 2005;48:6409
  2. Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.
    Pietrancosta et al.
    Bioorg.Med.Chem.Lett., 2005;15:1561
  3. Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.
    Zuco and Zunino
    Neoplasia, 2008;10:587
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