Cyclic Pifithrin-α hydrobromide
Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
Biological ActivityCyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α.
Barchechath et al.
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.
Pietrancosta et al.
Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.
Zuco and Zunino
Citation for Cyclic Pifithrin-α hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Cyclic Pifithrin-α hydrobromide include:
1 Citation: Showing 1 - 1
Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy.
Authors: Benkafadar Et al.
EMBO Mol Med 2017;9:7
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