Cyclic Pifithrin-α hydrobromide

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Cyclic Pifithrin-α hydrobromide | CAS No. 511296-88-1 | p53 Inhibitors
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Description: p53 inhibitor
Alternative Names: Pifithrin-β

Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide

Purity: ≥98%

Product Details
Citations (2)

Biological Activity

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at RT

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Citations for Cyclic Pifithrin-α hydrobromide

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