Cyclic Pifithrin-α hydrobromide

  ( 1 citations )    
Product Datasheet
Catalog Number:3843
Alternate Names:Pifithrin-β
Chemical Name:5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
Product Details
Citations (1)
Reviews
Biological Activity
Cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
Technical Data
  • M.Wt:
    349.29
  • Formula:
    C16H16N2S.HBr
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    511296-88-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyclic Pifithrin-α hydrobromide include:

1 Citations: Showing 1 - 1

  1. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy.
    Authors: Benkafadar Et al.
    EMBO Mol Med  2017;9:7

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