CYM 50358 hydrochloride

Key Product Details

Product Description

CYM 50358 hydrochloride is a potent S1P₄ antagonist (IC₅₀ = 25 nM). Displays selectivity for S1P₄ against S1P₁, S1P₂, S1P₃ and S1P₅ receptors.

Product Specifications for CYM 50358 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CYM 50358 hydrochloride

The following data is based on the product molecular weight 425.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.49 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Cencetti TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 2013 PMID: 23913862
• Guerrero Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P₄) receptor antagonists. Bioorg.Med.Chem.Lett. 2011 PMID: 21570287

Product Documents for CYM 50358 hydrochloride