CYM 50358 hydrochloride
Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Biological ActivityPotent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.
Guerrero et al.
TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.
Cencetti et al.
FASEB J., 2013;27:4532
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