7 results for "Sphingosine-1-phosphate Receptor Antagonists" in Products
Sphingosine-1-phosphate Receptor Antagonists
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes.
Both the S1P1 and S1P3 receptors are expressed ubiquitously. The S1P2 receptor is expressed postnatally in the brain, heart, lung, stomach, intestine and adrenal ...
S1P2 receptor antagonist
| Chemical Name: | 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide |
| Purity: | ≥98% |
Potent and selective S1P4 antagonist
| Chemical Name: | N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride |
| Purity: | ≥97% |
Potent and selective S1P1 receptor antagonist
| Alternate Names: | ML 056 |
| Chemical Name: | [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid |
| Purity: | ≥98% |
S1P1 and S1P3 antagonist
| Chemical Name: | 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide |
| Purity: | ≥95% |
Potent and selective S1P1 receptor antagonist
| Chemical Name: | 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid |
| Purity: | ≥98% |
S1P3 receptor antagonist
| Chemical Name: | N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide |
| Purity: | ≥98% |
Potent and selective S1P1 receptor antagonist; inhibits angiogenesis
| Chemical Name: | 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide |
| Purity: | ≥98% |
