Catalog Number: 3601
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Biological Activity
Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions
    Gonzalez-Cabrera et al.
    Mol.Pharmacol., 2008;74:1308

The citations listed below are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:

Showing Results 1 - 1 of 1

  1. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
    Authors: Li Et al.
    J Neuroinflammation
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