Potent and selective S1P1
agonist in vitro
= 1.35 nM). Activates S1P1
-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1
. Induces acute lymphopenia in mice. Brain penetrant.
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Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions
Gonzalez-Cabrera et al.
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