CYM 5442 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:3601
Chemical Name:2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Product Details
Citations (3)
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Reviews
Biological Activity
Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
Technical Data
  • M.Wt:
    445.94
  • Formula:
    C23H27N3O4.HCl
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1094042-01-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2.
    Authors: Chumanevich Et al.
    Mediators Inflamm  2016;2016:1503206
  2. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
    Authors: Li Et al.
    J Neuroinflammation  2015;12:70
  3. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
    Authors: Janes Et al.
    J Biol Chem  2014;289:21082

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