CYM 5442 hydrochloride

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CYM 5442 hydrochloride | CAS No. 1783987-80-3 | Sphingosine-1-phosphate Receptor Agonists
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Description: Selective S1P1 receptor agonist

Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride

Purity: ≥98%

Product Details
Citations (4)
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Reviews

Biological Activity

Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.

Technical Data

M.Wt:
445.94
Formula:
C23H27N3O4.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1783987-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions
    Gonzalez-Cabrera et al.
    Mol.Pharmacol., 2008;74:1308

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