CYM 5442 hydrochloride
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Biological ActivityPotent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions
Gonzalez-Cabrera et al.
Citations for CYM 5442 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:
4 Citations: Showing 1 - 4
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Authors: H?bner Et al.
Nat Commun 2018;9:4860
Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2.
Authors: Chumanevich Et al.
Mediators Inflamm 2016;2016:1503206
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Authors: Li Et al.
J Neuroinflammation 2015;12:70
The development and maintenance of PacT.-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Authors: Janes Et al.
J Biol Chem 2014;289:21082
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