Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50
= 0.04 μ
M in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
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All Tocris products are intended for laboratory research use only.
Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.
Breistøl et al.
Cancer Res., 1999;59:2944
Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells.
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Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
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