Catalog # Availability Size / Price Qty
Cytarabine | CAS No. 147-94-4 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Nucleoside analog; inhibits DNA replication
Alternative Names: Cytosine b-D-arabinofuranoside

Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to


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An inhibitor of neurogenesis
By Luiz Alexandre Magno on 07/16/2018
Application: Species: Mouse

Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.

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