Cytarabine

Tocris Bioscience | Catalog # 4520

Nucleoside analog; inhibits DNA replication
Tocris Bioscience

Key Product Details

Description

Nucleoside analog; inhibits DNA replication

Alternative Names

Cytosine b-D-arabinofuranoside
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Product Specifications for Cytarabine

Molecular Weight

243.22

Formula

C9H13N3O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

CAS Number

147-94-4

PubChem ID

114682

InChI Key

UHDGCWIWMRVCDJ-STUHELBRSA-N

SMILES

O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.32 100
DMSO 12.16 50

Preparing Stock Solutions for Cytarabine

The following data is based on the product molecular weight 243.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.56 mL 41.12 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.06 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

Product Documents for Cytarabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cytarabine

For research use only

⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Cytarabine (1)

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  • An inhibitor of neurogenesis
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Brain
    Verified Customer | Posted 07/16/2018
    Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.
    Cytarabine 4520

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