Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Biological ActivityNucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
Sampath et al.
Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models.
Breistøl et al.
Cancer Res., 1999;59:2944
Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells.
Yang et al.
Acta Pharmacol. Sin., 1986;7:368
Citations for Cytarabine
The citations listed below are publications that use Tocris products. Selected citations for Cytarabine include:
2 Citations: Showing 1 - 2
Systematic analysis of protein turnover in primary cells.
Authors: Mathieson Et al.
Nat Commun 2018;9:689
Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.
Authors: Bisikirska Et al.
Cancer Res 2016;76:664
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Reviews for Cytarabine
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Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.