Cytarabine

Catalog # Availability Size / Price Qty
4520/50
Cytarabine | CAS No. 147-94-4 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Nucleoside analog; inhibits DNA replication
Alternative Names: Cytosine b-D-arabinofuranoside

Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M.Wt:
243.22
Formula:
C9H13N3O5
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
147-94-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Cytarabine

The citations listed below are publications that use Tocris products. Selected citations for Cytarabine include:

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An inhibitor of neurogenesis
By Luiz Alexandre Magno on 07/16/2018
Application: Species: Mouse

Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.


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