Catalog Number: 4520
Alternate Names: Cytosine b-D-arabinofuranoside
Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Biological Activity
Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
Technical Data
  • M.Wt:
    243.22
  • Formula:
    C9H13N3O5
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    147-94-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.
    Breistøl et al.
    Cancer Res., 1999;59:2944
  2. Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells.
    Yang et al.
    Acta Pharmacol. Sin., 1986;7:368
  3. Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
    Sampath et al.
    Blood., 2006;107:2517

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