Catalog Number: 2902
Chemical Name: 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Biological Activity
Selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.
Technical Data
  • M.Wt:
    398.41
  • Formula:
    C23H18N4O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    301836-43-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. The selectivity of protein kinase inhibitors: a further update.
    Bain et al.
    Biochem.J., 2007;408:297
  2. Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5).
    Callahan et al.
    J.Med.Chem., 2002;45:999
  3. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
    Rena et al.
    EMBO Rep., 2004;5:60
Citations:

The citations listed below are publications that use Tocris products. Selected citations for D 4476 include:

4 Citations: Showing 1 - 4
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  1. GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
    Authors: Zhang Et al.
    PLoS Biol 2015;13:e1002129
  2. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
    Authors: Zemp Et al.
    J Cell Sci 2014;127:1242
  3. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1.
    Authors: Qian Et al.
    PLoS Pathog 2011;7:e1002065
  4. Perspectives on Regulatory T Cell Therapies.
    Authors: Probst-Kepper Et al.
    Toxins (Basel) 2009;36:302

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