Selective inhibitor of casein kinase 1 (CK1) and TGF-β
type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.
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The selectivity of protein kinase inhibitors: a further update.
Bain et al.
Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5).
Callahan et al.
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
Rena et al.
EMBO Rep., 2004;5:60
The citations listed below are publications that use Tocris products. Selected citations for D 4476 include:
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