D609

Tocris Bioscience | Catalog # 1437

Selective PC-PLC inhibitor
Tocris Bioscience

Key Product Details

Description

Selective PC-PLC inhibitor
View all Phospholipase Inhibitors »

Product Description

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Product Specifications for D609

Molecular Weight

266.46

Formula

C11H15OS2K

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate

CAS Number

83373-60-8

PubChem ID

4234241

InChI Key

IGULCCCBGBDZKQ-UHFFFAOYSA-M

SMILES

S=C(S[K])OC1CC2C3CCCC3C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.65 100

Preparing Stock Solutions for D609

The following data is based on the product molecular weight 266.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.53 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for D609

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for D609

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for D609 (2)

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  • great product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    100 μM treat 45min
    D609 1437
  • D609 does not inhibit LPA-induced COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. D609 was ineffective against LPA-induced COX-2 expression while other inhibitors showed inhibition.
    D609 1437

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