Catalog Number: 1437
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Biological Activity
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C.
    Drugs Exp.Clin.Res., 1996;22:287
  2. Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death.
    Li et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:7748
  3. D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant.
    Zhou et al.
    J.Pharmacol.Exp.Ther., 2001;298:103
  4. Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609).
    Tschiakowsky et al.
    Br.J.Pharmacol., 1994;113:664
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