DAP Kinase 2 Antibody

Novus Biologicals | Catalog # NB100-56344

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all DAPK2 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against KLH-conjugated synthetic peptides corresponding to amino acids 325-342 and 347-364 of human DAPK2. It will cross-react with mouse and rat DAPK2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DAP Kinase 2 Antibody

Western Blot: DAP Kinase 2 Antibody [NB100-56344]

Western Blot: DAP Kinase 2 Antibody [NB100-56344]

Western Blot: DAP Kinase 2 Antibody [NB100-56344] - Analysis of DAPK2 in rat kidney whole cell lysate using this antibody.

Applications for DAP Kinase 2 Antibody

Application
Recommended Usage

Western Blot

2-4 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DAPK2

DAPK2 is a 42 KDa calcium/calmodulin-dependent serine/threonine kinase localized in the cytoplasm. A member of DAP kinase family, DAPK2 has an N-terminal protein kinase domain, a conserved CAM binding domain and a 40A.A C-terminal tail required for homodimerization. Inactive DAPK2 is phosphorylated at conserved 'Ser-308', an inhibitory autophosphorylation site located within the CAM binding domain and is critical in inhibiting DAPK2 catalytic activation. Pro-apoptotic function of DAPK2 is activated by dephosphorylation, increase of intracellular Ca2+ levels, Ca2+ induced Calmodulin binding and homodimerization. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNa- induced caspase-independent autophagic type II cell death signaling. Northern Blot analysis detected abundant expression of DAPK2 mRNA in heart, lung and skeletal muscle.

Long Name

Death-associated Protein Kinase 2

Alternate Names

DAP Kinase 2, DRP-1

Entrez Gene IDs

23604 (Human); 13143 (Mouse); 300799 (Rat)

Gene Symbol

DAPK2

UniProt

Q9UIK4 (Human)

Additional DAPK2 Products

Product Documents for DAP Kinase 2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for DAP Kinase 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Intracellular Kinases

Citations for DAP Kinase 2 Antibody

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