DC-SIGN/CD209 Antibody (209MD26A)

Name: DC-SIGN/CD209 Antibody (209MD26A)
Brand: Novus Biologicals
SKU: NBP2-60971
Price: 299 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-60971

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Bovine, Goat, Sheep, Water Buffalo

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2A Clone # 209MD26A

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Product Specifications

Immunogen

Bovine expressed CD209

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Description

This monoclonal antibody is made in ascites form using mice. The ascites is collected and centrifuged to remove cells and large particles. The ascitic fluid is purified further by filtration through sequential filters with the last filter at 2 um. The concentration of the monoclonal antibody present in the ascites is determined with commercial radial immunodiffusion kits (1mg/ml).

Scientific Data Images for DC-SIGN/CD209 Antibody (209MD26A)

Flow Cytometry: DC-SIGN/CD209 Antibody (209MD26A) [NBP2-60971]

Flow Cytometry: DC-SIGN/CD209 Antibody (209MD26A) [NBP2-60971] - Obtained with bovine leukocytes

Applications for DC-SIGN/CD209 Antibody (209MD26A)

Application

Recommended Usage

Flow Cytometry

1:10 - 1:1000

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Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Ascites

Preservative

0.09% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DC-SIGN/CD209

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Long Name

Dendritic Cell-specific ICAM-3-grabbing Non-integrin 1

Alternate Names

CD209, CLEC4L, DC-SIGN1, DCSIGN

Gene Symbol

CD209

Additional DC-SIGN/CD209 Products

Product Documents for DC-SIGN/CD209 Antibody (209MD26A)

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Certificate of Analysis

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Product Specific Notices for DC-SIGN/CD209 Antibody (209MD26A)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.