Catalog Number: 0975
Chemical Name: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Biological Activity
Presynaptic depressant; highly potent agonist for group II mGlu receptors. Also available as part of the Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    203.15
  • Formula:
    C7H9NO6
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    147782-19-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Suntory Ltd.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
    Brabet et al.
    Neuropharmacology, 1998;37:1043
  3. Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
    Cartmell et al.
    Br.J.Pharmacol., 1998;123:497
  4. A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord.
    Ishida et al.
    Br.J.Pharmacol., 1993;109:1169
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DCG IV include:

24 Citations: Showing 1 - 10
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience 2016;6:7268
  3. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
    Authors: Suberbielle Et al.
    Acta Neuropathol Commun 2015;6:8897
  4. The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus.
    Authors: Martin Et al.
    Elife 2015;4
  5. Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.
    Authors: Decker Et al.
    Cell Rep 2015;3:23
  6. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    J Neurosci 2015;12:396
  7. Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
    Authors: Maurin Et al.
    PLoS One 2014;9:e87605
  8. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
    Authors: Yin Et al.
    J Neurosci 2014;34:79
  9. Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
    Authors: Vivar Et al.
    Eur J Neurosci 2012;35:76
  10. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  11. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One 2011;6:e27119
  12. Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
    Authors: Prickett Et al.
    Nat Genet 2011;43:1119
  13. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
    Authors: Sydow Et al.
    J Neurosci 2011;31:2511
  14. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci 2011;14:866
  15. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    Proc Natl Acad Sci U S A 2011;108:9993
  16. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Nat Commun 2010;30:3870
  17. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
    Authors: Galván Et al.
    J Neurosci 2010;30:2844
  18. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
    Authors: Torborg Et al.
    J Neurosci 2010;30:15628
  19. Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
    Authors: Hagena and Manahan-Vaughan
    Cereb Cortex 2010;20:1121
  20. Glutamatergic inhibition in sensory neocortex.
    Authors: Lee and Sherman
    Cereb Cortex 2009;19:2281
  21. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron 2008;58:925
  22. Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
    Authors: Suh Et al.
    Neuron 2008;58:736
  23. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A 2008;28:8677
  24. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
    Authors: Andrieux Et al.
    Genes Dev 2002;16:2350
Expand to show all 24 Citations

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