Chemical Name: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Biological ActivityDCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Brabet et al.
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Cartmell et al.
A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord.
Ishida et al.
Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues.
Ohfune et al.
Citations for DCG IV
The citations listed below are publications that use Tocris products. Selected citations for DCG IV include:
33 Citations: Showing 1 - 10
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Authors: Hashimotodani Et al.
Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
Authors: Sun Et al.
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Nat Commun 2017;8(1):1967
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
Authors: Miguel Angel Garcia-Bereguiain Et al.
The Journal of Neuroscience 2016;6:7268
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
Authors: Suberbielle Et al.
Acta Neuropathol Commun 2015;6:8897
The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus.
Authors: Martin Et al.
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.
Authors: Decker Et al.
Cell Rep 2015;3:23
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
Authors: Ben-Simon Et al.
J Neurosci 2015;12:396
Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
Authors: Maurin Et al.
PLoS One 2014;9:e87605
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Authors: Yin Et al.
J Neurosci 2014;34:79
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
Authors: Kaeser-Woo Et al.
J Neurosci 2013;33:9769
Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus.
Authors: Skucas Et al.
J Neurosci 2013;33:2338
Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
Authors: Vivar Et al.
Eur J Neurosci 2012;35:76
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
Authors: Taman and Ribeiro
PLoS One 2011;6:e27119
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
Authors: Prickett Et al.
Nat Genet 2011;43:1119
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Authors: Sydow Et al.
J Neurosci 2011;31:2511
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Authors: Straub Et al.
Nat Neurosci 2011;14:866
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Authors: Ster Et al.
Proc Natl Acad Sci U S A 2011;108:9993
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
Authors: Kim Et al.
Nat Commun 2010;30:3870
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
Authors: Galván Et al.
J Neurosci 2010;30:2844
Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
Authors: Torborg Et al.
J Neurosci 2010;30:15628
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
Authors: Hagena and Manahan-Vaughan
Cereb Cortex 2010;20:1121
Glutamatergic inhibition in sensory neocortex.
Authors: Lee and Sherman
Cereb Cortex 2009;19:2281
Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
Authors: Bagayogo and Dreyfus
ASN Neuro 2009;1
Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
Authors: Kim and Tsien
Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
Authors: Suh Et al.
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus.
Authors: Chiu and Castillo
BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
Authors: Wang Et al.
Proc Natl Acad Sci U S A 2008;28:8677
The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
Authors: Andrieux Et al.
Genes Dev 2002;16:2350
Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.
Authors: Yeckel Et al.
Nat Neurosci 1999;2:625
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