Defensin beta 1 Antibody

Novus Biologicals | Catalog # NBP3-11288

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit
View all Defensin beta 1 Primary Antibodies »

Product Specifications

Immunogen

Human beta-defensin 1

Clonality

Polyclonal

Host

Rabbit

Applications for Defensin beta 1 Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
For Western blot, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Defensin beta 1

Antimicrobial proteins (AMP) are a fundamental element of the primary response against pathogens. AMP's are small endogenous cationic molecules expressed by phagocytic and epithelial cells. The antimicrobial activity of AMP's is directed towards a broad spectrum of pathogens, like Gram-positive & negative bacteria, viruses, yeast and fungi. AMP's aid in innate and adaptive immunity via direct inactivation and by immunomodulatory activity like leukocyte migration. Defensins are the most prominent mammalian AMP's. Three defensin peptide families are identified, the alpha-, beta-, and theta-, defensins. They are characterized by a triple-stranded beta-hairpin structure, six disulfide-linked cysteine residues and a positive charge. They are synthesized as preproteins and undergo processing to become a fully active peptide. Defensins are divided in alpha- and beta-defensins depending on their disulfide bridging pattern. alpha- and beta-defensins modify cell migration and maturation, induce cytokines and trigger histamin and prostaglandin D2 release from mast cells. There are six alpha-defensins: HNP (human neutrophil peptide)-1 to -4, HD5 & 6. Human beta-defensin 1(hBD-1) is considered a prominent AMP in epithelial defense against infection. High expression levels have been found in the kidney and female reproductive tract, especially in pregnant women. Besides antimicrobial activity, hBD1 has an effect on chemoattractive immature dendritic cells and probably memory T cells. After reduction of disulphide-bridges hBD-1 becomes a potent antimicrobial peptide against the opportunistic pathogenic fungus Candida albicans and against anaerobic Gram positive commensals of Bifidobacterium and Lactobacillus species.

Alternate Names

BD1, BD-1, beta-defensin 1, beta-defensin-1, DEFB-1, DEFB101, defensin, beta 1HBD-1, hBD-1, HBD1MGC51822

Gene Symbol

DEFB1

Additional Defensin beta 1 Products

Product Documents for Defensin beta 1 Antibody

Certificate of Analysis

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Download SDS

Product Specific Notices for Defensin beta 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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