Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Biological ActivityTricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Plasma membrane monoamine transporters: structure, regulation and function.
Torres et al.
NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Zhao et al.
Citations for Desipramine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:
6 Citations: Showing 1 - 6
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
Authors: LaRocca Et al.
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
Proc Natl Acad Sci U S A 2015;40:766
Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
Authors: Bucher Et al.
J Cereb Blood Flow Metab 2014;34:1128
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram.
Authors: Choi Et al.
Korean J Physiol Pharmacol 2013;17:321
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