Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Biological ActivityDesipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Plasma membrane monoamine transporters: structure, regulation and function.
Torres et al.
NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr.
Zhao et al.
Citations for Desipramine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:
8 Citations: Showing 1 - 8
A mesocortical DA circuit enables the cultural transmission of vocal behaviour.
Authors: Tanaka Et al.
Combinatorial Expression of Grp and Neurod6 Defines DA Neuron Populations with Distinct Projection Patterns and Disease Vulnerability.
Authors: Kramer Et al.
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
Authors: LaRocca Et al.
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
Proc Natl Acad Sci U S A 2015;40:766
Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
Authors: Bucher Et al.
J Cereb Blood Flow Metab 2014;34:1128
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by desipr. and cital.
Authors: Choi Et al.
Korean J Physiol Pharmacol 2013;17:321
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