Catalog Number: 3067
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Biological Activity
Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
Technical Data
  • M.Wt:
    302.84
  • Formula:
    C18H22N2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    58-28-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Plasma membrane monoamine transporters: structure, regulation and function.
    Torres et al.
    Nat.Rev.Neurosci., 2003;4:13
  2. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
    Zhao et al.
    Neuropsychopharmacol., 2008;33:3190
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

4 Citations: Showing 1 - 4
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  1. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
    Authors: LaRocca Et al.
    Neuropsychopharmacology 2015;6:e1773
  2. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Proc Natl Acad Sci U S A 2015;40:766
  3. Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab 2014;34:1128
  4. Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram.
    Authors: Choi Et al.
    Korean J Physiol Pharmacol 2013;17:321

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