Dexrazoxane hydrochloride

Catalog # Availability Size / Price Qty
3857/10
3857/50
DNA Topoisomerase Inhibitors Small Molecule
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Description: Topoisomerase II inhibitor
Alternative Names: ICRF-187

Chemical Name: 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Technical Data

M.Wt:
304.73
Formula:
C11H16N4O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1263283-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats.
    Lebrecht et al.
    Br.J.Pharmacol, 2007;151:771
  2. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187.
    Classen et al.
    Proc.Natl.Acad.Sci., 2003;100:10629
  3. Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz.
    Spallarossa et al.
    J.Pharmacol.Exp.Ther., 2010;332:87

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Citation for Dexrazoxane hydrochloride

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