Dexrazoxane hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:3857
Alternate Names:ICRF-187
Chemical Name:4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Technical Data
  • M.Wt:
    304.73
  • Formula:
    C11H16N4O4.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1263283-43-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dexrazoxane hydrochloride include:

1 Citations: Showing 1 - 1

  1. Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.
    Authors: Gardner Et al.
    Breast Cancer Res  2011;13:R53

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