Dihydrokainic acid

  ( 14 citations )    
Product Datasheet
Catalog Number:0111
Chemical Name:(2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM). Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    215.25
  • Formula:
    C10H17NO4
  • Solubility:
    Soluble to 25 mM in water
  • Storage:
    Store at RT
  • CAS No:
    52497-36-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dihydrokainic acid include:

14 Citations: Showing 1 - 10
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  1. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci  2015;8:425
  2. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Mol Brain  2015;8:35
  3. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes.
    Authors: Petr Et al.
    J Neurosci  2015;35:5187
  4. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.
    Authors: Foran Et al.
    Glia  2014;62:1241
  5. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Br J Pharmacol  2014;171:5417
  6. Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
    Authors: Tse Et al.
    Vision Res  2014;103:49
  7. Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.
    Authors: McKeown Et al.
    Dev Biol  2012;362:162
  8. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
    Authors: Hobo Et al.
    Neurosci Lett  2011;502:52
  9. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
    Authors: Parri Et al.
    Eur J Neurosci  2010;32:29
  10. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus.
    Authors: Mulholland Et al.
    Alcohol  2009;43:45
  11. Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?
    Authors: David Et al.
    J Neurosci  2009;29:10588
  12. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    J Neurosci  2008;28:1479
  13. Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia.
    Authors: Weller Et al.
    Neuroscience  2008;155:1204
  14. Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation.
    Authors: Chu Et al.
    Stroke  2007;38:177
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