Dihydrokainic acid

Catalog # Availability Size / Price Qty
Dihydrokainic acid | CAS No. 52497-36-6 | Glutamate (EAAT) Transporter Inhibitors
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Description: EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake

Chemical Name: (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

Product Details
Citations (16)
Supplemental Products

Biological Activity

Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).

Technical Data

Soluble to 25 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Dihydrokainic acid

The citations listed below are publications that use Tocris products. Selected citations for Dihydrokainic acid include:

16 Citations: Showing 1 - 10

  1. Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
    Authors: Romanos Et al.
    Commun Biol  2019;2:127
  2. Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex.
    Authors: Gasull-Camôs Et al.
    Neuropharmacology  2018;139:41
  3. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci  2015;8:425
  4. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Mol Brain  2015;8:35
  5. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes.
    Authors: Petr Et al.
    J Neurosci  2015;35:5187
  6. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.
    Authors: Foran Et al.
    Glia  2014;62:1241
  7. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Br J Pharmacol  2014;171:5417
  8. Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
    Authors: Tse Et al.
    Vision Res  2014;103:49
  9. Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.
    Authors: McKeown Et al.
    Dev Biol  2012;362:162
  10. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
    Authors: Hobo Et al.
    Neurosci Lett  2011;502:52


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