(±)-NBI 74330

Key Product Details

Product Description

(±)-NBI 74330 is a potent and selective CXCR3 antagonist; potently inhibits ¹²⁵I-CXCL10 binding to CXCR3 (pK_i = 8.13). Inhibits calcium mobilization in response to CXCL11 and CXCL10 in RBL cells. Exhibits no significant effect on chemotaxis induced by CXCR4 or CCR7. Displays a five-fold greater affinity for CXCR3 than (±)-AMG 487.

This product is racemic.

Product Specifications for (±)-NBI 74330

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-NBI 74330

The following data is based on the product molecular weight 605.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.30 mL	16.51 mL	33.03 mL
2.5 mM	0.66 mL	3.30 mL	6.61 mL
5 mM	0.33 mL	1.65 mL	3.30 mL
25 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Verzijl Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18270317
• Heise Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J.Pharmacol.Exp.Ther. 2005 PMID: 15761110
• Storelli Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists. Arch.Pharm. 2007 PMID: 17562560

Product Documents for (±)-NBI 74330