DMP-1 Antibody

Novus Biologicals | Catalog # NBP1-20908

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all DMP-1 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-ENSEQANTQDSG corresponding to internal region according to NP_004398.1, NP_001073380.1.

Epitope

C terminus

Specificity

This antibody is expected to recognize both reported isoforms (NP_004398.1; NP_001073380.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for DMP-1 Antibody

Western Blot: DMP-1 Antibody [NBP1-20908]

Western Blot: DMP-1 Antibody [NBP1-20908]

Western Blot: DMP-1 Antibody [NBP1-20908] - (1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for DMP-1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 55 kDa band observed in human Ileum and kidney lysates (calculated MW of 55.8 kDa band according to NP_004398.1 and of 54.1 according to NP_001073380.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DMP-1

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Long Name

Dentin Matrix Protein 1

Alternate Names

DMP1

Entrez Gene IDs

1758 (Human)

Gene Symbol

DMP1

UniProt

NP_004398.1 (Human)

Additional DMP-1 Products

Product Documents for DMP-1 Antibody

Certificate of Analysis

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Product Specific Notices for DMP-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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