Dopa Decarboxylase/DDC Antibody

R&D Systems | Catalog # PPS065

R&D Systems
Discontinued Product
PPS065 has been discontinued. View all Dopa Decarboxylase/DDC products.

Key Product Details

Species Reactivity

Human, Rat, Bovine, Canine, Guinea Pig, Rabbit, Sheep

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG
View all Dopa Decarboxylase/DDC Primary Antibodies »

Product Specifications

Immunogen

Dopa Decarboxylase/DDC

Specificity

Human, bovine, canine, guinea pig, rabbit, rat, and sheep ~55 kDa DOPA Decarboxylase (DDC) in Western blots.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Scientific Data Images for Dopa Decarboxylase/DDC Antibody

Detection of Dopa Decarboxylase/DDC antibody by Western Blot.

Detection of Dopa Decarboxylase/DDC by Western Blot.

Western blot of bovine adrenal medulla lysate showing specific immunolabeling of the ~55 kDa DDC protein.

Applications for Dopa Decarboxylase/DDC Antibody

Application
Recommended Usage

Western Blot

1:1000 dilution

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

For long-term storage, ≤ -20° C is recommended. Product is stable at ≤ -20° C for at least 1 year.

Background: Dopa Decarboxylase/DDC

DOPA decarboxylase (Aromatic-L-amino acid decarboxylase; also DDC) is a 54 kDa member of the alpha -family of pyroxidal phosphate enzymes. Functional DDC is a homodimeric, pyridoxal phosphate-dependent enzyme that calatyzes the decarboxylation of DOPA to dopamine, L-tryptophan to tryptamine, and 5-hydroxytryptophan to serotonin. Both dopamine and serotonin are important neurotransmitters. It also demonstrates deaminase activity, and is regulated by O2 availability. Bovine DDC is 487 amino acids (aa) in length and contains an N-terminal decarboxylase domain (aa 35-414) and a C-terminal pyroxidal binding site (L303). Bovine DDC is 88% and 86% aa identical to human and rat DDC, respectively.

References

  1. Kang, U.J. and T.H. Joh (1990) Brain Res. Mol. Brain Res. 8:83.
  2. Ichinose, H. et al. (1989) Biochem. Biophys. Res. Commun. 164:1024.
  3. Moore, P.S. et al. (1996) Biochem. J. 315:249.
  4. Bertoldi, M. and C.B. Voltattorni (2003) Biochim. Biophys. Acta 1647:42.

Alternate Names

AADC, DDC

Entrez Gene IDs

1644 (Human)

Gene Symbol

DDC

Additional Dopa Decarboxylase/DDC Products

Product Documents for Dopa Decarboxylase/DDC Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Dopa Decarboxylase/DDC Antibody

For research use only

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