Doxazosin mesylate

Tocris Bioscience | Catalog # 2964

α1 antagonist
Tocris Bioscience

Key Product Details

Description

α1 antagonist

Alternative Names

UK 33274
View all Adrenergic alpha-1 Receptor Antagonists »

Product Description

Doxazosin mesylate is a selective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.

Scientific Data Images for Doxazosin mesylate

Reduced viability of differentiated cardiomyocytes exposed to cardiotoxic small molecules

Reduced viability of differentiated cardiomyocytes exposed to cardiotoxic small molecules.

The viability of differentiated cardiomyocytes was assessed using a Resazurin metabolism assay. A) Untreated cells metabolize Resazurin (Catalog # AR002) to produce resorufin, a fluorescent molecule that can be measured using a fluorometric plate reader. Resorufin fluorescence accumulated in untreated cardiomyocytes. Cells treated with the cardiotoxic small molecules Staurosporine (blue; Catalog # 1285), a non-selective protein kinase inhibitor, or Doxazosin (tan; Catalog # 2964), an alpha 1 antagonist, did not metabolize Resazurin, as shown by lack of fluorescence accumulation, indicating a loss of viability upon treatment. B) Cell morphology of untreated, Staurosporine-treated, and Doxazosin-treated cardiomyocytes was assessed by brightfield microscopy.

Product Specifications for Doxazosin mesylate

Molecular Weight

547.58

Formula

C23H25N5O5.CH3SO3H

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate

CAS Number

77883-43-3

PubChem ID

62978

InChI Key

VJECBOKJABCYMF-UHFFFAOYSA-N

SMILES

NC2=NC(N3CCN(C(C4COC(C=CC=C5)=C5O4)=O)CC3)=NC1=CC(OC)=C(OC)C=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.07 75

Preparing Stock Solutions for Doxazosin mesylate

The following data is based on the product molecular weight 547.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.43 mL 12.17 mL 24.35 mL
3.75 mM 0.49 mL 2.43 mL 4.87 mL
7.5 mM 0.24 mL 1.22 mL 2.43 mL
37.5 mM 0.05 mL 0.24 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for Doxazosin mesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Doxazosin mesylate

For research use only

Citations for Doxazosin mesylate

Customer Reviews for Doxazosin mesylate (1)

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  • Used to investigate cell metabolism
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 01/27/2023
    The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.

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