Catalog Number: 2964
Alternate Names: UK 33274
Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate
Biological Activity
Selective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.
Technical Data
  • M.Wt:
    547.58
  • Formula:
    C23H25N5O5.CH3SO3H
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    77883-43-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding functional and in vivo studies.
    Kenny et al.
    Br.J.Pharmacol., 1996;118:871
  2. The α1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.
    Alabaster and Davey
    Br.J.Clin.Pharmacol., 1986;21:9S
  3. Chiral selective effects of doxazosin enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats.
    Ma et al.
    Acta Pharmacol.Sinica, 2006;27:1423
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Doxazosin mesylate include:

2 Citations: Showing 1 - 2
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  1. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala.
    Authors: Diaz Et al.
    Front Cell Neurosci 2014;2:46
  2. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov 2013;3:1364

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