Catalog Number: 2964
Alternate Names: UK 33274
Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate
Biological Activity
Selective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding functional and in vivo studies.
    Kenny et al.
    Br.J.Pharmacol., 1996;118:871
  2. The α1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.
    Alabaster and Davey
    Br.J.Clin.Pharmacol., 1986;21:9S
  3. Chiral selective effects of doxazosin enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats.
    Ma et al.
    Acta Pharmacol.Sinica, 2006;27:1423
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