Doxazosin mesylate

Catalog # Availability Size / Price Qty
Doxazosin mesylate | CAS No. 77883-43-3 | Adrenergic alpha-1 Receptor Antagonists
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Description: α1 antagonist
Alternative Names: UK 33274

Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products

Biological Activity

Selective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.

Technical Data

Soluble to 75 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The α1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.
    Alabaster and Davey
    Br.J.Clin.Pharmacol., 1986;21:9S
  2. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding functional and in vivo studies.
    Kenny et al.
    Br.J.Pharmacol., 1996;118:871
  3. Chiral selective effects of doxa. enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats.
    Ma et al.
    Acta Pharmacol.Sinica, 2006;27:1423

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