Catalog Number: 1285
Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Biological Activity
Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).
Technical Data
  • M.Wt:
    466.54
  • Formula:
    C28H26N4O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    62996-74-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Staurosporine include:

10 Citations: Showing 1 - 10
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  1. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells.
    Authors: Chen Et al.
    Mol Pharmacol 2016;11:e0156145
  2. Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.
    Authors: Sonamoto Et al.
    Eneuro 2015;5:12728
  3. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons.
    Authors: Piccart Et al.
    J Neurosci 2015;35:11144
  4. FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles.
    Authors: Faulkner Et al.
    PLoS One 2015;2:e0055
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Eur J Neurosci 2015;10:e0125974
  6. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
    Authors: Barcomb Et al.
    J Biol Chem 2013;84:834
  7. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
    Authors: Schönbrunn Et al.
    J Med Chem 2013;56:3768
  8. Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults.
    Authors: Kawamoto Et al.
    PLoS One 2012;45:58
  9. Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by α-tocopherol and MEK inhibition.
    Authors: Kondo Et al.
    Braz J Med Biol Res 2010;285:13079
  10. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury.
    Authors: Chen Et al.
    J Biol Chem 2006;281:2764

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