DPM2 Antibody

Novus Biologicals | Catalog # NBP1-28470

Novus Biologicals
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Key Product Details

Species Reactivity

Mouse

Applications

Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all DPM2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-YVMLKSQKITKKAQ corresponding to C-Terminus according to NP_034203.1.

Epitope

C terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Description

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Applications for DPM2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000
Application Notes
WB: Preliminary experiments gave an approx. 25 kDa band in mouse eye lysates after 0.02 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 9.4 kDa band according to NP_034203.1. The 25 kDa band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DPM2

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. (provided by RefSeq)

Alternate Names

dolichol phosphate-mannose biosynthesis regulatory protein, dolichol phosphate-mannose synthase 2, dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit, FLJ80013, MGC111193, MGC21559

Entrez Gene IDs

13481 (Mouse)

Gene Symbol

DPM2

UniProt

NP_034203.1 (Human)

Additional DPM2 Products

Product Documents for DPM2 Antibody

Certificate of Analysis

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Product Specific Notices for DPM2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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