Chemical Name: 5-Iodoisoquinoline
Biological ActivityDSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for DSRM-3716
There are currently no reviews for this product. Be the first to review DSRM-3716 and earn rewards!
Have you used DSRM-3716?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image