dTAGV-1 hydrochloride

Tocris Bioscience | Catalog # 7374

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use
Tocris Bioscience

Key Product Details

Description

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use
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Product Description

dTAGV-1 hydrochloride is a hydrochloride salt of dTAGV-1 (Cat. No. 6914). Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T½ = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hr*ng mL-1 and CL = 9.05 mL min-1 kg-1

Negative control dTAGV-1-NEG (Cat. No. 6915) also available.

Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for dTAGV-1 hydrochloride

Molecular Weight

1284.01

Formula

C68H90N6O14S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride

CAS Number

2624313-16-0

InChI Key

WZEDGWVEEAWMSD-LNVAYBNASA-N

SMILES

C[C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H](NC(CCCCCCNC(COC2=CC=CC=C2[C@H](OC([C@@H]3CCCCN3C([C@@H](CC)C4=CC(OC)=C(OC)C(OC)=C4)=O)=O)CCC5=CC(OC)=C(OC)C=C5)=O)=O)C(C)(C)C)=O)=O)C6=CC=C(C=C6)C7=C(N=CS7)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 128.4 100

Preparing Stock Solutions for dTAGV-1 hydrochloride

The following data is based on the product molecular weight 1284.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.78 mL 3.89 mL 7.79 mL
5 mM 0.16 mL 0.78 mL 1.56 mL
10 mM 0.08 mL 0.39 mL 0.78 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for dTAGV-1 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for dTAGV-1 hydrochloride

For research use only

Citations for dTAGV-1 hydrochloride

Customer Reviews for dTAGV-1 hydrochloride (1)

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  • Degradation of Myc fusion protein
    Name: Bikesh Nirala
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma cell lines
    Verified Customer | Posted 06/21/2022
    I used dTAG-v1 for in-vivo and in-vitro protein degradation and it worked perfectly.
    dTAGV-1 hydrochloride 7374

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