E6AP/UBE3A Antibody [Biotin]

Name: E6AP/UBE3A Antibody [Biotin]
Brand: Novus Biologicals
SKU: NB500-239B
Price: 539 USD
Availability: InStock

Novus Biologicals | Catalog # NB500-239B

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Canine (100%), Equine (100%), Guinea Pig (100%), Monkey (100%), Primate (100%), Rabbit (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Immunoprecipitation

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

View all E6AP/UBE3A Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a portion of human ubiquitin protein ligase E3A encoded within exon 6 (LocusLink ID 7337).

Reactivity Notes

Based on 100% sequence identity, this antibody is predicted to react with Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crabeating macaque, Naked mole rat, Thirteen-lined ground squirrel and Northern white-cheeked gibbon.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for E6AP/UBE3A Antibody [Biotin]

Application

Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: E6AP/UBE3A

UBE3A encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Long Name

Human Papillomavirus E6-associated Protein

Alternate Names

ANCR, EPVE6AP, HPVE6A, UBE3A

Gene Symbol

UBE3A

Additional E6AP/UBE3A Products

Product Documents for E6AP/UBE3A Antibody [Biotin]

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Certificate of Analysis

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Product Specific Notices for E6AP/UBE3A Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

E3 Ubiquitin Ligases

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