Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
Biological ActivityEB 1089 is a vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.
Hoyer-Hansen et al.
Cell Death Differ., 2005;12:1297
Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57.
Lu et al.
Mol.Cancer Ther., 2008;7:1268
EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells.
Bhatia et al.
Mol.Cancer Ther., 2009;8:1787
Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer.
Abdaimi et al.
Cancer Res,, 1999;59:3325
The calci. analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung.
Ormerod et al.
Citations for EB 1089
The citations listed below are publications that use Tocris products. Selected citations for EB 1089 include:
3 Citations: Showing 1 - 3
Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.
Authors: Hiranuma Et al.
FEBS Open Bio 2016;6:914
A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
Authors: Sharma Et al.
VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
Authors: Solomon Et al.
Mol Cancer Res 2014;12:1166
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