EB 1089

Catalog # Availability Size / Price Qty
EB 1089 | CAS No. 134404-52-7 | VDR-like Receptor Agonists
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Description: Vitamin D receptor (VDR) agonist
Alternative Names: Seocalcitol

Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

EB 1089 is a vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Technical Data

Soluble in DMSO and in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.
    Hoyer-Hansen et al.
    Cell Death Differ., 2005;12:1297
  2. Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57.
    Lu et al.
    Mol.Cancer Ther., 2008;7:1268
  3. EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells.
    Bhatia et al.
    Mol.Cancer Ther., 2009;8:1787
  4. Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer.
    Abdaimi et al.
    Cancer Res,, 1999;59:3325
  5. The calci. analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung.
    Ormerod et al.
    Exp.Lung.Rs., 2008;34:155

Product Datasheets

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Citations for EB 1089

The citations listed below are publications that use Tocris products. Selected citations for EB 1089 include:

3 Citations: Showing 1 - 3


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