EB 1089

  ( 3 citations )    
Product Datasheet
Catalog Number:3993
Alternate Names:Seocalcitol
Chemical Name:(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
Product Details
Citations (3)
Reviews
Biological Activity
Vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).
Technical Data
  • M.Wt:
    454.68
  • Formula:
    C30H46O3
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    134404-52-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for EB 1089 include:

3 Citations: Showing 1 - 3
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  1. Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.
    Authors: Hiranuma Et al.
    FEBS Open Bio  2016;6:914
  2. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
    Authors: Sharma Et al.
    Oncotarget  2015;10:2346
  3. VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
    Authors: Solomon Et al.
    Mol Cancer Res  2014;12:1166

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